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Best Weed Killer Home Depot (2024 Update)

With summer finally here, it’s time to get outside and enjoy the sunshine. But if you look in your yard and see weeds popping up everywhere, it can put a damper on your outdoor fun. Before reaching for a chemical weed killer, take some time to consider your options. The best weed killer for your lawn will depend on the type of grass you have, the specific weeds invading your yard, and how comfortable you are using chemicals on your property.

When it comes to selecting a weed killer, you first need to identify the unwelcome plants. Are they broadleaf weeds like dandelions and clover? Or clumping grasses like crabgrass and nutsedge? This will help narrow down your choices. You’ll also want to read the label to see what specific weeds the product targets. Once you know what you’re up against, you can look for the most effective killer that won’t harm your lawn.

Some key questions to ask yourself when choosing a weed killer: Is it selective or non-selective? What application method makes the most sense for your yard? How quickly does it work? How long does the effect last? What’s the toxicity and environmental impact? Do you need an all-natural formula or are you comfortable with chemicals? What’s your budget?

Taking the time to do a little research beforehand goes a long way. Pick the best weed killer for your specific weed problem and lawn type. Then enjoy a freshly manicured yard all season long.

20 Best Weed Killer Home Depot (20 Sellers)

1. All-In-One Lawn Weed Crabgrass Killer – 24 Oz.

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2. Syngenta 46256 Tenacity 8oz Herbicide, Clear

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3. Bioadvanced Lawn Weed & Crabgrass Killer, All In One, Ready-To-Spray – 32 Fl Oz

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Units in Package 1
Unit Size 32 fl oz
Directions Pesticide Storage: Store in original container in a cool, dry place, out of the reach of children, preferably a locked storage cabinet. Protect from freezing. Read the label first! Kills: Broadleaf Weeds: Dandelion, chickweed, and clovers. Grassy Weeds: Crabgrass and over 200 other listed weeds. Where to Use: On lawns without harming lawn grasses Bermudagrass (Application to Bermudagrass may cause temporary yellowing or discoloration but full recovery can be expected.), Buffalograss, Kentucky Bluegrass, Ryegrass, Fescue, Zoysia, Bentgrass. Directions for Use: It is a violation of Federal law to use this product in a manner inconsistent with its labeling. How Much to Use: Measure area to be sprayed. Calculate square feet by multiplying length times width. This bottle will treat 5,000 square feet in about 5 minutes (actual time will vary depending on water pressure). The maximum application rate to turf is 1.5 pounds of 2,4-D acid equivalent per acre per application per site. The maximum number of broadcast applications per treatment site is 2 per year. How to Use: Shake well before use. Connect: (1) Shake well before use; (2) Securely connect sprayer to garden hose; (3) Be sure than on/off switch is in off position, toward hose end of sprayer; (4) Turn on water at faucet; (5) For first time use, remove plastic shipping lock from beneath switch. Spray: (1) Extend hose to farthest area to be treated, point sprayer nozzle in direction to be sprayed; (2) Begin spraying push on/off switch forward into on position; (3) Walk at a steady pace while spraying, using an even sweeping motion, and slightly overlap treated areas. Work back toward faucet to avoid walking over wet, treated grass. Finish: (1) To stop spraying push on/off switch to off position; (2) Turn off water at faucet; (3) Relieve water pressure in hose by turning on/off switch back to on position until water slows to drip, then return on/off switch to off position; (4) Disconnect sprayer from hose. For Best Results When to Apply: Spray when: Weeds are small and actively growing; temperature is below 90 degrees F. Do not apply to bermudagrass lawns when daytime temperatures exceed 85 degrees F. Certain hard-to-kill weeds may be retreated in 2 weeks if necessary. lf more than 2 applications are needed, use a spot treatment lawn weed killer such as BioAdvanced science-based solutions all in-one lawn weed & crabgrass killer ready to use; Do not apply while grass is emerging from dormancy; Newly seeded lawn may be sprayed after fourth mowing; Bare spots may be seeded 4 weeks after application; Keep product spray off plants growing in or around the lawn such as trees, shrubs, flowers, perennials, groundcovers, vegetables, & herbs. Mowing: Do not mow for 1 to 2 days after spraying; Clippings from the first three mowings should be left on the treated area. Do not use the clippings from the treated areas as mulch or compost around flowers, ornamentals, trees, or in vegetable gardens. Watering: If lawn is dry, water 1 to 2 days before using this product; Rain or watering 1 hour after application will not wash away effectiveness. How it Works: This product contains three proven weed killers to control lawn weeds & crabgrass down to the roots without harming your lawn when used as directed.
Ingredients Active Ingredients: 2,4-D, Dimethylamine Salt-4.85%, Quinclorac-1.61%, Dicamba, Dimethylamine Salt-0.45%, Other Ingredients:-93.09%, Total-100.00%. This Product Contains: 0,343 Lb 2.4-Dichlorophenoxyacetic Acid Equivalent per Gallon or 4.03%, 0,137 Lb 3.7 –Dichloro-8-Quinolinecarboxylic Acid per Gallon or 1.61%, 0,031 Lb 3.6-Dichloro-O-Anisic Acid Equivalent per Gallon or 0.37%, Isomer Specific by Aoac Method.
Warnings Keep out of reach of children. Caution: See back panel for additional precautionary statements. Precautionary Statements: Caution: Hazards to Humans and Domestic Animals: Harmful if swallowed; Causes moderate eye irritation; Avoid contact with eyes, skin, or clothing; When using this product, wear long-sleeved shirt, long pants, socks, shoes, and rubber gloves. After using this product: Rinse gloves before removing and wash hands; If product gets on skin, wash thoroughly with soap & water; If product gets on clothing, remove clothing as soon as possible and launder clothing separately before reuse. First Aid: If Swallowed: Call a poison control center or doctor immediately for treatment advice; Have person sip a glass of water if able to swallow; Do not induce vomiting unless told to do so by a poison control center or doctor; Do not give anything by mouth to an unconscious person. If in Eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes; Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye; Call a poison control center or doctor for further treatment advice. Note: When calling poison control center, have this product label accessible. If seeking treatment at an emergency room or doctor's office, bring this product label to show medical personnel. You may call toll-free 1-877-229-3763 for medical emergency information. Do not apply this product in a way that will contact any person or pet, either directly or through drift. Keep people and pets out of the area during application. Do not allow people or pets to enter the treated area until spray has dried.

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4. Preen 5.625 Lb Garden Weed Preventer Plus Plant Food

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5. 9963794 – Eraser Weed & Grass Killer Concentrate, 16 Oz.

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6. Hi-Yield Fertilome Selective Weed Killer Concentrate 1 Gal.

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this product is the easier and best to use. results are phenomenal and it will not hurt your grass. weeds all gone.lakecrazey

7. Spectracide Weed Stop For Lawns Concentrate – 32 Fl Oz

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8. Ecosmart Organic Weed And Grass Killer, 64-Ounce

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Did not kill a single weedi_love-tintin

9. Scotts Weed Control For Lawns

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10. Pulverize 32 Oz. Weed Brush And Vine Killer Concentrate

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Weight 3 oz

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They do not store poisons in their shop. It took 5 days to arrive.zvladan

11. Voluntary Purchasing Hi-Yield Killzall Weed & Grass Killer – 1 Gal Jug

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It takes a week to do the trick, but works great.anonymous
This product works and for a reasonable cost. Also, it saves many hours of manual weed trimming.english00hunting
Great product but pricing itself out of my budget.anonymous

12. Bioadvanced 704198a Weed And Grass Killer, 1 Gallon

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13. Southern Ag Lawn Weed Killer With Trimec – 0.474 L Jug

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Pet safe Yes, when used as directed on label
NOT FOR SALE TO CA,MA, MN
Coverage Area Up to 12,800 sq. ft

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It works fast and good product for the money.082270kim
Great product. works fasaalexander69
The only product I use. It also kills English Ivy and Sumac varieties.teapotz

14. Voluntary Purchasing Group Hi-Yield Killzall Weed & Grass Killer – 2.5 Gal Jug

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That's the best weed killer I've ever usedanonymous
the only one i buy it is the bestanonymous

15. Hi Yield 16 Oz Grass Killer

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16. Bonide Burnout Weed & Grass Killer Concentrate

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17. Roundup Weed & Grass Killer Iii, Ready-To-Use, Value Size – 30 Fl Oz

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Units in Package 1
Unit Size 30 fl oz
Directions Directions for Use: It is a violation of Federal law to use this product in a manner inconsistent with its labeling. Always read and follow label directions. How to Assemble and Use instructions: 1. Remove sprayer. Pull cord/tubing all the way out. 2. Insert plug into knob opening or spout on cap. 3. Turn knob to on or flip up spout until fully upright. Adjust nozzle to the desired spray setting. Flip-up spout must remain up while spraying. How to Apply: Adjust nozzle to the desired spray setting. Spray the weeds or grasses you want to kill until thoroughly wet. When spot treating weeds around desirable plants, shield plants from drift with a sheet of cardboard or plastic. If desirable plants are accidently sprayed, rinse off immediately with water. Important: Do not spray plants or grasses you like – they will die. Not recommended for spot weed control in lawns since this product kills lawn grasses. Do not allow treated weeds to come in contact with desirable plants until spray has dried. When to Apply: Apply when weeds are actively growing. For best results, apply during warm, sunny weather above 60 degrees F. Product is effective when applications are made under cool and cloudy conditions as low as 50 degrees F. Spray when air is calm to prevent drift to desirable plants. Rainproof: Rain or watering 10 minutes after application will not wash away effectiveness. Weeds yellow and wilt within hours with complete kill in 1 to 2 weeks for annual weeds. Perennial weeds such as poison ivy may take 4 or more weeks for complete kill. When to Replant: All ornamental flowers, trees and shrubs may be planted 1 day after application. Lawn grasses, herbs, vegetables and fruits may be planted 3 days after application. How to Refill: To refill this empty container, pour product carefully and directly from the Roundup Ready-To-Use Weed & Grass Killer Ill container designated as the ready-to-use refill container. Do not add water. Additional Tips: For lawn replacement: Use this product to kill an existing lawn and weeds before planting a new lawn or prior to laying a patio, sidewalk or driveway. Wait at least 3 days for weeds and lawn to die. Repeat if necessary. Rake or till to prepare area for planting seed or sod. For Flowerbed and Garden Preparation: Use this product to kill weeds, grasses and brush before planting flowers, fruits, vegetables, trees or shrubs. Wait 1 to 3 days after last application before planting garden. See when to replant section for details. Storage and Disposal: Pesticide Storage: Turn knob on cap to off or flip spout down. No need to disconnect trigger sprayer. Completely dispense product in sprayer prior to storage. Close nozzle on trigger sprayer. Place sprayer back in side clip. Store product in original container in a safe place away from direct sunlight. Keep from freezing. If frozen, allow to thaw and shake well before using. Pesticide Disposal and Container Handling: Nonrefillable container. Do not reuse or refill this container unless the directions for use allow a different concentrated or ready-to-use product to be diluted in or poured directly into the container. Reuse or refill this container according to the directions contained in the how to refill section. If Empty: Place in trash or offer for recycling, if available. If Partly Filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.
Ingredients Active Ingredients: Glyphosate, Isopropylamine Salt (Contains 0.1 lbs Glyphosate Acid Equivalent per US Gallon) (2.0%), Pelargonic Acid and Related Fatty Acids (2.0%). Other Ingredients (96.0%). Total (100%).
Warnings Keep out of reach of children. Caution: See back panel booklet for additional precautionary statements. Precautionary Statements: Hazards to humans & domestic animals. Keep out of reach of children. Caution: Causes moderate eye irritation. Avoid contact with eyes or clothing; Wash thoroughly with soap and water after handling. People and pets may enter treated area after spray has dried. First Aid: If in Eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present after first 5 minutes, then continue rinsing eyes. Call a poison control center or doctor for treatment advice. Emergency Medical Information: Have the product container or label with you when calling a poison control center or doctor, or going for treatment. You may contact 1-80C-246-7219 for emergency medical treatment information. This product is identified as Roundup Ready-To-Use Weed & Grass Killer III, EPA Reg. No. 71995-33. Environmental Hazards: To protect the environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or surface waters. Applying this product in calm weather when rain is not predicted for the next 24 hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area. Notice: To the extent consistent with applicable law, buyer assumes all responsibility for safety and use not in accordance with directions.

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18. Roundup 5705010 Concentrate Extended Control Weed & Grass Killer, 1 Qt

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19. Ortho 32 Oz Weed B Gon Chickweed & Clover Killer

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Weight 2 lb

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20. Spectracide Weed & Grass Killer – 1 Gal, 128 Fl Oz

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Units in Package 1
Unit Size 1 gl
Directions For outdoor residential use only. Kills the Root: For best results, apply when temperature is above 60 degrees F. Shake well. Open flip top closure firmly insert hose plug. Operating Instructions for Accushot Sprayer: 1. Shake well before each use. 2. Remove sprayer from side holster. Unwrap the tubing. Gently pull tubing out. 3. Open flip-top closure. 4. Securely snap the hose plug into opening in cap until it snaps into place. 5. Slide switch on hose plug counterclockwise to open. 6. Remove plastic tab near bottom of sprayer to activate batteries. 7. Twist nozzle to adjust spray from close to spray or stream. 8. When priming the sprayer, hold sprayer level to the ground. Squeeze and hold trigger until liquid comes out the nozzle. Sprayer may not prime if it is held at an angle. Once primed, it will spray in any direction. When to Use: 60 degrees F. For best results, apply above 60 degrees F. Works faster at higher temperatures. See inside booklet for complete directions for use, including how to use, how and when to apply, and replanting tips. Read entire label before use. How to Use the Accushot Sprayer: 1. Aim toward target area to be treated and away from people and pets. 2. To improve accuracy, use slider to extend wand. 3. Press the trigger to spray 4. Release the trigger to stop spray. After Use: 1. Twist sprayer nozzle completely to close position. 2. Tun hose plug switch clockwise to closed. 3. Secure sprayer tip down in holster 4. Failure to adjust nozzle completely to close position and properly secure sprayer in holster may result in leakage and damage to property or injury to people or animals. Keep Reusable Accushot Sprayer for Use with Spectracide Weed & Brass Killer. To Replace Batteries: 1. Use screwdriver to open battery compartment 2. Remove used batteries and insert four new AA batteries in correct positions as marked per diagram inside of battery compartment. Never insert the positive end where the negative end belongs and vice versa. Always use a complete set of new batteries of the same type when replacing batteries. Never mix alkaline, carbon-zinc or rechargeable batteries. 3. Securely close battery compartment door. 4. Always follow manufacturer's recommendations for use and disposal of batteries. Additional Operating Notes: Do not submerge in water. Before each use, inspect sprayer carefully – make sure hose is flexible and not kinked, worn or cracked, and that all connections are tight. When storing sprayer for prolonged periods, remove batteries. Directions for Use: Stop. Read entire label before use. It is a violation of federal law to use this product in a manner inconsistent with its labeling. Do not allow people or pets to touch treated plants until the sprays have dried. Application Restrictions: Do not apply this product in a way that will contact any person or pet, either directly or through drift. Only persons applying this product may be in the area during application. Do not mow, cut or otherwise disturb treated vegetation, weeds or plants for at least seven days following application. Do not use on or around edible feed or food crops. When to Apply: For best results, apply during warm, sunny weather (above 60 degrees F) when weeds are actively growing. Rainfall or watering 15 minutes after application will not wash away effectiveness. To avoid drift to desirable plants, apply when the air is calm. When to Replant: All ornamental flowers, trees and shrubs may be planted one day after application. For Lawn Renovation/Replacement: Determine size of area to be treated – measure length and width in feet, then multiply to determine coverage area in square feet (length x width). 2. Use this product to remove the old lawn and existing weeds and grasses. 3. For best results, apply in spring or fall, when daytime temperatures are at least 60 degrees F. 4. Under dry conditions, water lawn every other day for a week before applying this product. 5. Do not mow for seven days before or after treatment. 6. One gallon treats 300 sq ft. Tips for Replanting: Wait seven days after last application to rake, till or replant with seed or sod. Rake up and remove loosened thatch or debris. Mix in starter fertilizer and soil amendments, if needed. Level the soil. Apply seed according to directions on seed package, or install sod. Grass seed must have good contact with soil to germinate and grow. Keep area moist for two weeks to establish new lawn, then water as needed. How to Use: Spectracide Weed & Grass Killer, is pre-mixed and ready to use and is formulated for spot treatment of weeds and grasses. Use it on driveways and walkways, or around fences, trees, flower beds, shrubs and other areas in your yard. How to Apply (Visual symptoms and time to complete kill will depend on weed and grass type, temperature and application rate): Completely cover the leaves of the target vegetation. Do not overspray. Sprayed plants begin yellowing and wilting in about 24 hours, with complete kill, including the roots, in one to two weeks. Protect desirable plants with a piece of plastic or cardboard. If desirable plants are accidentally sprayed, wash plants with water immediately. Not recommended for spot weed treatment in established lawns since lawn grasses will also be killed. Storage and Disposal: Pesticide Storage: turn the nozzle to close position. To prevent leakage, place sprayer in holster. Store this product only in its original container in a secure storage area away from sources of heat or open flame and in an area inaccessible to children and pets. Keep from freezing. Pesticide Disposal: do not discard the accushot sprayer. Keep the accushot sprayer for use on spectracide weed & grass killer nonrefillable container. Do not reuse or refill this container unless the directions for use allow a different concentrated) product to be diluted in the container. If Empty: place in trash or offer for recycling if available, If Partly Filled: call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.
Ingredients Active Ingredients: Diquat Dibromide 0.12%, Fluazifop-p-Butyl 0.06%, Dicamba, Dimethylamine Salt 0.04%. Other Ingredients 99.78%. Total 100.00%.
Warnings Caution: See back booklet for additional precautionary statements. Precautionary Statements: Hazards to Humans and Domestic Animals: Caution: Causes moderate eye imitation. Avoid contact with eyes or clothing. Personal Protective Equipment (PPE): Wear long-sleeved shirt, long pants, shoes and socks. User Safety Recommendations: Users should wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. Users should remove clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing users should remove clothing and personal protective equipment immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. Environmental Hazards: This pesticide is toxic to aquatic invertebrates. Do not apply directly to water or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment washwaters or rinsate. To protect the environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or surface waters. Applying this product in calm weather when rain is not predicted for the next 24 hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area. Notice: To the extent required by applicable law, buyer assumes all responsibility for safety and use not in accordance with directions. First Aid: If in Eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a Poison Control Center or doctor for treatment advice. If on Skin or Clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a Poison Control Center or doctor for treatment advice. Have the product container or label with you when calling a Poison Control Center on doctor, or going for treatment. Keep out of reach of children.

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