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Best Enzyme Cleaner For Drains (2024 Update)

Clogged and slow-moving drains are a nuisance that no homeowner wants to deal with. Dirty pipes filled with hair, soap scum, and other gunk can make water back up or drain slowly after using sinks, tubs, and showers. While you may be tempted to reach for harsh chemical drain cleaners, enzyme-based drain cleaners offer a safer and more effective solution. When searching for the best enzyme cleaner for drains, there are a few key factors to consider.

First, examine the types of enzymes contained in the drain cleaner. Strong enzyme drain cleaners contain a blend of protease, amylase, and cellulase enzymes that actively digest organic matter that causes clogs. Second, look for drain cleaners with beneficial bacteria strains. These natural microorganisms help break down residue and keep drains free-flowing.

You’ll also want to verify if the enzyme cleaner is safe for all drain materials. Enzyme cleaners that are harmless to PVC, plastic, metal, and septic system pipes ensure no damage as they clean. Finally, compare product formulas. Liquid or gel enzyme cleaners that cling to the sides of drains maximize cleaning contact time. Some also feature grease-cutting agents for especially stubborn clogs.

Do enzyme drain cleaners live up to their claims of dissolving gunk and clearing clogs? Are these septic system-safe solutions superior to caustic drain cleaners? Continue reading our guide to learn the answers to these questions and determine the best enzyme cleaner for drains.

20 Best Enzyme Cleaner For Drains (20 Sellers)

1. Green Gobbler Drain Clog Dissolver – 2 Pack, 15.5 Fl Oz Bottles

Product Details:

Specifications:

Units in Package 2
Unit Size 15.5 fl oz bottles
Directions Instructions for Use: For sinks and tubs: Pour one full chamber of product slowly into the drain. Allow product to sit in drain as long as possible (at least 15-30 minutes) and then flush with hottest water possible. For extremely difficult obstructions, pour second treatment and allow to sit in drain overnight. Then flush with boiling hot water. (use caution when handling boiling water). For toilets: Pour both chambers slowly into the toilet, allow product to work at least 2 hours or preferably overnight. Once water has come down to a normal level flush. Handling and Storage: Store in a cool, dry place away from incompatible materials. Do not mix with any other drain openers or cleaning chemicals. Keep container tightly closed when not in use. After using the first chamber replace cap.
Warnings Danger! Harmful if swallowed. Can cause burns. Keep out of reach of children. Carefully read precautions on rear panel. Danger! Contains lauramine oxide (derived from plant based material) & other proprietary ingredients. Read label before use. Can cause eye and skin burns. Harmful if swallowed. Avoid contact with eyes and skin. Do not take internally. Wash hands after use. First Aid: Eye Contact: Immediately flush with water at least 15 minutes. Get immediate medical attention. Skin Contact: Immediately wash with plenty of water for several minutes. Get medical attention if irritation persists. If swallowed: Call a Poison Control Center or a doctor. If person is alert, have them rinse their mouth out with water. For question or in case of exposure, call 1-800-424-9300.

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2. Zep Enzymatic Drain Cleaner – 18 Fl Oz Jar

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3. Biokleen Bac Out Drain Care Gel- 32 Oz Bottle

Product Details:

Specifications:

Units in Package 1
Unit Size 32 fl oz
Directions For best results, do not run water for several hours after treatment. For slow moving drains pour 8 oz down drain in circular motion. Repeat 2-3 times per week or until drain returns to a normal flow. To maintain drain, garbage disposal & odors pour 4 oz down drain in circular motion. Repeat 2x per week.
Ingredients Water (Filtered), Glycerin (Vegetable), Caprylyl/Capryl Glucoside (Plant Based Surfactant), C10-16 Alkyl Glucoside (Plant Based), Citrus Terpenes, Xanthan Gum, Dipropylene Glycol, Benzisothiazolinone, Viable Bacillus Cultures.
Warnings Keep out of reach of children.

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4. Biofresh – Enzyme Drain Cleaner & Odor Eliminator. Deodorizes And Unclogs Smelly Garbage Disposals, Washing Machines And Slow Drains. Super

Product Details:

Specifications:

Is Discontinued By Manufacturer No
Product Dimensions 3.5 x 3.5 x 9 inches; 2 Pounds

Reviews:

Cleans up tanks quickly and efficiently A couple cap fulls does the jobpizzola123

5. Green Gobbler 1 Gal. Enzyme Drain Cleaner

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Specifications:

Reviews:

I put 4 gallons in my cesspool about three weeks ago and haven't seen any change in drainage.ron
Had a clogged drain and when my plumber took care of the clog he recommended this product to prevent future problems.Baby Jo
I've used it twice now and it works for like 2 days and then the drain smell is back.Erin

6. Rejuvenate Cleaner, Disposer & Pipe, Lavender Scent – 7.7 Oz

Product Details:

Specifications:

Units in Package 1
Unit Size 7.7 oz
Directions (Read entire label before using). Rejuvenate Disposer & Pipe Cleaner is designed for use in properly working disposers and will not clear a clogged drain. 1. Operate Disposer with water until it is empty. Turn off disposer, and run a strong stream of hot water into disposal sink, just to the side of disposal, so it is not running directly into disposal for approximately one minute. Reduce hot water stream to a pencil width trickle. 2. (Do not open pod). With Disposer off and water still at a trickle, insert one unopened biodegradable pod completely into the disposer. Turn on disposer and operate for 10 seconds. Purple cleaning foam may rise into sink or both sinks if double sink. Turn off disposer and keep water trickle for about 30 more seconds, then turn on high until all foam goes away. Note: Cleaning cycle is complete when cleaning foam entirely disappears from disposer (approx. 1-2 min). Use weekly to prevent build-up and odors. Storage/Disposal: Store pods in original pouch and reseal after each use.
Warnings Caution: Eye & skin irritant. Harmful if swallowed. Keep out of reach of children and pets. Read carefully other cautions on back panel. Caution: Eye & skin irritant. Harmful if swallowed. Keep out of reach of children and pets. Contains malic acid and sodium lauryl sulfate. Do not open pod. Do not get contents in eyes or on skin. Do not ingest. Do not mix with any other cleaner or chemical. First Aid: If In Eyes: Flush with plenty of water for 15 minutes and seek immediate medical attention. If On Skin: Flush with water. If irritation persists, get medical attention. If Swallowed: Do not induce vomiting. Rinse mouth with water. Call a poison control center (1-800-222-1222) or doctor immediately for treatment advice.

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7. Thrift T-600 Alkaline Based 6 Lb. Granular Drain Cleaner

Product Details:

Specifications:

Product Dimensions 4 x 8 x 11 inches
Is Discontinued By Manufacturer No
Item Package Quantity 1
Included Components 6 lb bottle of thrift

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8. Green Gobbler Ultimate Main Drain Opener + Drain Cleaner + Hair Clog Remover – 64 Oz (Main Lines Sinks Tubs Toilets Showers Kitchen Sinks)

Product Details:

Specifications:

Size 64 Fl Oz (Pack of 1)

Reviews:

This is the best drain opener in the world. It's saved me from calling the plumber many times.Master

9. Green Gobbler Drain & Disposal Cleaner, Fresh Citrus Scent – 32 Fl Oz

Product Details:

Specifications:

Units in Package 1
Unit Size 32 fl oz
Directions Garbage Disposals: Pour in 4 oz then cover drain and turn on disposal for 2 seconds. Leave product in disposal overnight then flush with hot water in the morning. Drains: Pour 4 oz into drain, leave the drain overnight then flush with hot water in the morning. Keep container closed when not in use.
Ingredients Surfactant Blend (Proprietary), Isopropyl Alcohol (CAS 67-63-0), Hydroxyethyl Cellulose (CAS 9004-62-0), Solvent (CAS Proprietary).
Warnings Eye and skin irritant. May be harmful if swallowed. Carefully read precautions on rear panel. First Aid: If in Eyes: Immediately flush eyes with water for at least 15 minutes then get immediate medical attention. Remove contact lenses, if present and easy to do after the first 5 minutes, then continue flushing. If on Skin (or Hair): Wash skin with water. Get medical attention if irritation persists. If Inhaled: Move to fresh air. Get medical attention if irritation persists. If Ingested: If conscious, rinse mouth with water and give one glass of water to drink. Do not induce vomiting. Call a physician or poison center. In case of emergency call 1-800-424-9300. If Skin Irritation Occurs: Get medical attention. Wash all contaminated clothing before use. In Case of Fire: Use CO2, dry chemical, foam or water spray to extinguish. Store in a cool, well-ventilated place. Dipose of contents and container in accordance with local, state and federal regulations. Keep out of reach of children. Read label before use. Causes eye and skin irritation. Wear eye protection and protective gloves. Wash hands thoroughly after handling. Contains surfactants and isopropanol. Avoid contact with eyes, skin and clothing. Avoid breathing mists. Wash hands with water after handling.

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Love At home shoppingImelda
This stuff works great. I will be buying more. I will be buying more. One thing I hate is a smelly garbage disposal.lighthouse-west
I have tried numerous products to help with my garbage disposal odor. This is truly the only one that works!Linda

10. Blue Monster Drain Banger 1 Lb. Flakes Drain Opener & Cleaner 76055

Product Details:

Specifications:

Product Form Flakes
Package Quantity 1
Country of Origin United States of America

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11. Green Gobbler Drain Strips, Bio-Flow, 12 Pack – 12 Pack, 0.12 Oz Strips

Product Details:

Specifications:

Units in Package 12
Unit Size 0.12 oz strips
Warnings First Aid: Eye Contact Immediately flush eyes with water for at least 20 minutes then get immediate medical attention. Remove contact lenses, if present an easy to do after the first 5 minutes, then continue flushing. Skin Contact: Wash skin with water. Get medical attention if irritation persists. Ingestion: If conscious, rinse mouth with water and give one glass of water to drink Dot not induce vomiting. Call a physician or poison center immediately. Severe eye irritant. Skin irritant. May be harmful if swallowed. Carefully read precautions on rear panel. Contains sodium dodecylbenzenesulfonate. Avoid contact with the eyes, skin and clothing. Avoid breathing mists. Wash hands with water after handling. Keep container closed when not in use. Keep out of reach of children.

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12. Mrs. Meyer's Probiotic Drain Maintenance – Lemon Verbena (32 Oz)

Product Details:

Specifications:

Product Dimensions 3.7 x 3.7 x 9.7 inches; 2.33 Pounds
Country of Origin USA

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13. Plink Freshener & Cleaner, Fizzy Drain, Fresh Lemon – 6 Pack, 1.37 Oz

Product Details:

Specifications:

Units in Package 6
Unit Size 1.37 oz
Directions Not for use in garbage disposal. Directions for Use: Read entire label before using. 1. Run water first to ensure it is hot and then turn off water before proceedings. 2. Place Plink table on top of the sink drain. 3. Plink your drain by running a stream of hot water directly onto the tablet for 20 seconds or until gond. 4. Turn off water. Your just plinked your drain!
Warnings Caution: Eye irritant. Read carefully other cautions on back panel. Caution: Eye irritant. Keep out of reach of children & pets.Contains Citric Acid and Sodium Carbonate. Avoid contact with eyes and prolonged contact with skin. Do not ingest. Do not mix with any other chemicals. First Aid: If in Eyes: Flush with water for at least 15 minutes. If irritation persists, get medical attention. If on skin: Flush thoroughly with water. If swallowed: Do not induce vomiting. Drink 1-2 glosses of water. Call a poison control center (1-800-222-12221 or doctor for treatment advice. Storage/Disposal: Store in original package in a dry area away from children.

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14. Earthworm Drain Cleaner – Deodorizer – Natural And Family-Safe 64 Ounce

Product Details:

Specifications:

Is Discontinued By Manufacturer No
Package Dimensions 9.7 x 4.7 x 4.7 inches; 4.3 Pounds

Reviews:

Use it to keep drains clear. Really seems to work. Nice scent. Much happier using this than toxic chemicals.juditkelle_21

15. Green Gobbler Enzymes For Grease Trap & Sewer – Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil In Sewer Lines, Septic Tanks

Product Details:

Specifications:

Size 128 Fl Oz (Pack of 1)

Reviews:

great neat and secure packaging. delivery came through unscathedAnthony V.

16. Green Gobbler 31 Oz. Drain Clog Dissolver

Product Details:

Specifications:

Assembled Product Weight 2.4 lb
Contained Battery Type 1
Form Liquid
Container Type Bottle
Assembled Product Dimensions (L x W x H) 2.50 x 4.00 x 9.50 Inches

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17. Green Gobbler Drain Opening Pacs – 3 Pack, 6.53 Oz Packs

Product Details:

Specifications:

Units in Package 3
Unit Size 6.53 oz packs
Directions Easy to use: No measuring, no spilling, no mess. 1. Cut! 2. Pour! 3. Clear! Instructions for use: 1). Cut open one pac and pour entire contents into drain. 2). Add small amount of hot water, just enough to make sure no excess powder remains on surfaces. 3). Let stand for 15-30 minutes then flush with plenty of hot water. Note: For tough clogs use second pac and let stand overnight, then flush with plenty of very hot water. For best results use hottest water possible). For Toilets: Empty two packets into toilet, allow to sit overnight. (if water level is abnormally high, allow water to reduce by approx 50% and then flush). Maintenance Tip: For optimal results, use in each drain in your home once a month. Additional instructions for use inside. Storage: Do not open pouches until ready to use. Use entire contents of the pac and dispose of empty pac where inaccessible by children and pets. Store unopened pacs only and keep in a dry place. If product becomes wet, do not use or handle and carefully dispose of product.
Warnings Danger: Harmful if swallowed causes eye burns. See additional warning on back. Danger: Keep out of the reach of children prevent contact with eyes. May irritate skin, avoid contact with skin and clothing do not breathe powder. Wash hand after use contains sodium bisulfate. First Aid: In case of contact immediately flush eyes with running water for at least 20 minutes. Call a physician or poison center immediately. If swallowed, do not induce vomiting. Call a doctor or poison control center. Note: Rarely odor may occur when clearing clog. This is a normal occurrence produced, not by green gobbler, but by organic substances being broken down in pipes. If needed, provide extra ventilation and/or run extra water in drain to dissipate odor. Contains no VOCs. Do not mix with bleach, other household cleaning agents or other drain openers. Contains monosodium sulfate and other ingredients.

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18. Thrift Marketing T-200 Drain Cleaner 2 Lbs

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19. Thrift Drain Granular Cleaner – 2 Lb, 3-Pack

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Recommended Location Indoor

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20. Drano Commercial Line Clog Remover, Max Gel, Pro Strength – 42 Fl Oz

Product Details:

Specifications:

Units in Package 1
Unit Size 42 fl oz
Directions 1. Pour 1/2 bottle slowly into drain. 2. Wait for 15-30 minutes. 3. Flush drain with hot water. Repeat steps if necessary. Product Guide: Max Gel: Hair clogs; Standing water; Slow drains; Pipe build up. Safe on metal & plastic pipes. Garbage Disposal Drains: Follow same directions. If drain has not cleared, do not turn on disposal since product may splash back. Consult plumber.
Ingredients Bleach, Water, Cleaning Agent, Caustic, Corrosion Inhibitor.
Warnings First Aid: Give immediately. Eyes: Rinse immediately with water. Remove contact lenses, then flush eyes with water for 15 minutes. If Swallowed: Rinse mouth, Drink a cup of milk or water. Do not induce vomiting. If On Skin: Remove affected clothing. Flush skin with water for 15 minutes. In all cases, Call Poison Control Center or Physician. Contains sodium hypochlorite, sodium hydroxide, and sodium silicate. Danger: Keep out of reach of children and pets. Can cause burns on contact. Harmful if swallowed. Read back label carefully. Do not use with plunger or in toilet. Important: Open carefully and keep hands, face, children and pets away. Do not squeeze bottle, avoid splashing, and clean up spills at once. Never use a plunger during or after use of Drano Max Gel because product may still be present if drain is not clear. Do not reuse empty container. Rinse container and replace cap before discarding. Danger: Keep out of reach of children and pets. Harmful if swallowed. May burn eyes, skin, and mucous membranes on contact. Do not use or mix Drano Max Gel with any other cleaners or chemicals, as hazardous fumes or a violent reaction may result. If gases are released, leave area immediately-ventilate if possible. Keep container tightly closed and store in a locked cabinet.

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